潘李锋-中国科学院大学-UCAS
[中文]
[English]
研究领域
招生信息
教育背景
工作经历
教授课程
专利与奖励
出版信息
科研活动
指导学生
基本信息
潘李锋 男 博导 中国科学院上海有机化学研究所电子邮件： panlf@sioc.ac.cn通信地址： 上海市零陵路345号邮政编码： 200032
研究领域
1.以人类疾病为导向，综合利用结构生物学、生物化学、化学生物学等手段的交叉学科研究，具体包括：研究与癌症、神经退行性疾病相关的细胞自噬（Autophagy）通路，揭示相关未知的分子机制和致病机理；研究与癌症等疾病相关的重要E3泛素酶和去泛素酶的结构与功能关系，并研发相关的小分子抑制剂，用于后续相关的化学生物学和潜在的疾病治疗研究。2. 活性小分子的化学生物学研究，具体包括：天然活性小分子与靶点蛋白相互作用的机制研究；基于SAR-by-NMR方法，针对与癌症等疾病相关的重要生物靶点的小分子先导物的筛选和优化，及后期基于此先导物的机理和功能研究。
招生信息
招生专业
0703Z1-化学生物学070303-有机化学070302-分析化学
招生方向
活性小分子与蛋白质相互作用的机制研究蛋白质核磁共振分析与疾病相关的蛋白质的结构与功能研究
教育背景
2005-09--2010-06 香港科技大学 博士2001-09--2005-07 复旦大学 本科
工作经历
工作简历
2013-01~2013-04,美国哈佛大学, 访问学者2012-08~现在, 中国科学院上海有机化学研究所, 研究员2011-03~2012-08,香港科技大学, 研究助理教授2010-08~2011-02,香港科技大学, 助理研究员
社会兼职
2017-11-01-2021-10-31,中国生物物理学会生物磁共振专业委员会副秘书长, 副秘书长2014-10-01-2016-10-31,《中国化学快报》青年编委会委员, 青年编委会委员
教授课程
生物有机化学
专利与奖励
奖励信息
（1）&nbsp上海市科技系统青年五四奖章,&nbsp市地级,&nbsp2018（2）&nbsp中国化学会青年化学奖,&nbsp一等奖,&nbsp其他,&nbsp2017
出版信息
发表论文
[1] Jianping Liu, Yaru Wang, Danni Wang, Yingli Wang, Xiaolong Xu, Yuchao Zhang, Ying Li, Mingfang Zhang, Xinyu Gong, Yubin Tang, Liqiang Shen, Miao Li, Lifeng Pan. Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri. Proceedings of the National Academy of Sciences of the United States of America[J]. 2022, 119(12):&nbsp[2] Klionsky, Daniel J, AbdelAziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie H, Abudu, Yakubu Princely, AcevedoArozena, Abraham, Adamopoulos, Iannis E, Adeli, Khosrow, Adolph, Timon E, Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat B, Agnello, Maria, Agostinis, Patrizia, Agrewala, Javed N, Agrotis, Alexander, Aguilar, Patricia, V, Ahmad, S Tariq, Ahmed, Zubair M, AhumadaCastro, Ulises, Aits, Sonja, Aizawa, Shu, Akkoc, Yunus, Akoumianaki, Tonia, Akpinar, Hafize Aysin, AlAbd, Ahmed M, AlAkra, Lina, AlGharaibeh, Abeer, AlaouiJamali, Moulay A, Alberti, Simon, AlcocerGomez, Elisabet, Alessandri, Cristiano, Ali, Muhammad, AlBari, M Abdul Alim, Aliwaini, Saeb, Alizadeh, Javad, Almacellas, Eugenia, Almasan, Alexandru, Alonso, Alicia, Alonso, Guillermo D, AltanBonnet, Nihal, Altieri, Dario C, Alves, Sara, da Costa, Cristine Alves, Alzaharna, Mazen M, Amadio, Marialaura, Amantini, Consuelo, Amaral, Cristina, Ambrosio, Susanna, Amer, Amal O, Ammanathan, Veena, An, Zhenyi, Andersen, Stig U, Andrabi, Shaida A, AndradeSilva, Magaiver, Andres, Allen M, Angelini, Sabrina, Ann, David, Anozie, Uche C, Ansari, Mohammad Y, Antas, Pedro, Antebi, Adam, Anton, Zurine, Anwar, Tahira, Apetoh, Lionel, Apostolova, Nadezda, Araki, Toshiyuki, Araki, Yasuhiro, Arasaki, Kohei, Araujo, Wagner L, Araya, Jun, Arden, Catherine, Arevalo, MariaAngeles, Arguelles, Sandro, Arias, Esperanza, Arikkath, Jyothi, Arimoto, Hirokazu, Ariosa, Aileen R, ArmstrongJames, Darius, ArnaunePelloquin, Laetitia, Aroca, Angeles, Arroyo, Daniela S, Arsov, Ivica, Artero, Ruben, Asaro, Dalia Maria Lucia, Aschner, Michael, Ashrafizadeh, Milad, AshurFabian, Osnat, Atanasov, Atanas G, Au, Alicia K, Auberger, Patrick, Auner, Holger W, Aurelian, Laure, Autelli, Riccardo, Avagliano, Laura, Avalos, Yenniffer, Aveic, Sanja, Aveleira, Celia Alexandra, AvinWittenberg, Tamar, Aydin, Yucel, Ayton, Scott, Ayyadevara, Srinivas, Azzopardi, Maria, Baba, Misuzu, Backer, Jonathan M, Backues, Steven K, Bae, DongHun, Bae, OkNam, Bae, Soo Han, Baehrecke, Eric H, Baek, Ahruem, Baek, SeungHoon, Baek, Sung Hee, Bagetta, Giacinto, BagniewskaZadworna, Agnieszka, Bai, Hua, Bai, Jie, Bai, Xiyuan, Bai, Yidong, Bairagi, Nandadulal, Baksi, Shounak, Balbi, Teresa, Baldari, Cosima T, Balduini, Walter, Ballabio, Andrea, Ballester, Maria, Balazadeh, Salma, Balzan, Rena, Bandopadhyay, Rina, Banerjee, Sreeparna, Banerjee, Sulagna, Bao, Yan, Baptista, Mauricio S, Baracca, Alessandra, Barbati, Cristiana, Bargiela, Ariadna, Barila, Daniela, Barlow, Peter G, Barmada, Sami J, Barreiro, Esther, Barreto, George E, Bartek, Jiri, Bartel, Bonnie, Bartolome, Alberto, Barve, Gaurav R, Basagoudanavar, Suresh H, Bassham, Diane C, Jr, Robert C Bast, Basu, Alakananda, Batoko, Henri, Batten, Isabella, Baulieu, Etienne E, Baumgarner, Bradley L, Bayry, Jagadeesh, Beale, Rupert, Beau, Isabelle, Beaumatin, Florian, Bechara, Luiz R G, Beck, George R, Jr, Beers, Michael F, Begun, Jakob, Behrends, Christian, Behrens, Georg M N, Bei, Roberto, Bejarano, Eloy, Bel, Shai, Behl, Christian, Belaid, Amine, BelgarehTouze, Naima, Bellarosa, Cristina, Belleudi, Francesca, Bello Perez, Melissa, BelloMorales, Raquel, de Oliveira Beltran, Jackeline Soares, Beltran, Sebastian, Benbrook, Doris Mangiaracina, Bendorius, Mykolas, Benitez, Bruno A, BenitoCuesta, Irene, Bensalem, Julien, Berchtold, Martin W, Berezowska, Sabina, Bergamaschi, Daniele, Bergami, Matteo, Bergmann, Andreas, Berliocchi, Laura, BerliozTorrent, Clarisse, Bernard, Amelie, Berthoux, Lionel, Besirli, Cagri G, Besteiro, Sebastien, Betin, Virginie M, Beyaert, Rudi, Bezbradica, Jelena S, Bhaskar, Kiran, BhatiaKissova, Ingrid, Bhattacharya, Resham, Bhattacharya, Sujoy, Bhattacharyya, Shalmoli, Bhuiyan, Md Shenuarin, Bhutia, Sujit Kumar, Bi, Lanrong, Bi, Xiaolin, Biden, Trevor J, Bijian, Krikor, Billes, Viktor A, Binart, Nadine, Bincoletto, Claudia, Birgisdottir, Asa B, Bjorkoy, Geir, Blanco, Gonzalo, BlasGarcia, Ana, Blasiak, Janusz, Blomgran, Robert, Blomgren, Klas, Blum, Janice S, BoadaRomero, Emilio, Boban, Mirta, BoeszeBattaglia, Kathleen, Boeuf, Philippe, Boland, Barry, Bomont, Pascale, Bonaldo, Paolo, Bonam, Srinivasa Reddy, Bonfili, Laura, Bonifacino, Juan S, Boone, Brian A, Bootman, Martin D, Bordi, Matteo, Borner, Christoph, Bornhauser, Beat C, Borthakur, Gautam, Bosch, Jurgen, Bose, Santanu, Botana, Luis M, Botas, Juan, Boulanger, Chantal M, Boulton, Michael E, Bourdenx, Mathieu, Bourgeois, Benjamin, Bourke, Nollaig M, Bousquet, Guilhem, Boya, Patricia, Bozhkov, Peter, V, Bozi, Luiz H M, Bozkurt, Tolga O, Brackney, Doug E, Brandts, Christian H, Braun, Ralf J, Braus, Gerhard H, BravoSagua, Roberto, BravoSan Pedro, Jose M, Brest, Patrick, Bringer, MarieAgnes, BrionesHerrera, Alfredo, Broaddus, V Courtney, Brodersen, Peter, Alvarez, Elida M C, Brodsky, Jeffrey L, Brody, Steven L, Bronson, Paola G, Bronstein, Jeff M, Brown, Carolyn N, Brown, Rhoderick E, Brum, Patricia C, Brumell, John H, BrunettiPierri, Nicola, Bruno, Daniele, BrysonRichardson, Robert J, Bucci, Cecilia, Buchrieser, Carmen, Bueno, Marta, BuitragoMolina, Laura Elisa, Buraschi, Simone, Buch, Shilpa, Buchan, J Ross, Buckingham, Erin M, Budak, Hikmet, Budini, Mauricio, Bultynck, Geert, Burada, Florin, Burgoyne, Joseph R, Buron, M Isabel, Bustos, Victor, Buttner, Sabrina, Butturini, Elena, Byrd, Aaron, Cabas, Isabel, CabreraBenitez, Sandra, Cadwell, Ken, Cai, Jingjing, Cai, Lu, Cai, Qian, Cairo, Montserrat, Calbet, Jose A, Caldwell, Guy A, Caldwell, Kim A, Call, Jarrod A, Calvani, Riccardo, Calvo, Ana C, Barrera, Miguel CalvoRubio, Camara, Niels Os, Camonis, Jacques H, Camougrand, Nadine, Campanella, Michelangelo, Campbell, Edward M, CampbellValois, FrancoisXavier, Campello, Silvia, Campesi, Ilaria, Campos, Juliane C, Camuzard, Olivier, Cancino, Jorge, de Almeida, Danilo Candido, Canesi, Laura, Caniggia, Isabella, Canonico, Barbara, Canti, Carles, Cao, Bin, Caraglia, Michele, Carames, Beatriz, Carchman, Evie H, CardenalMunoz, Elena, Cardenas, Cesar, Cardenas, Luis, Cardoso, Sandra M, Carew, Jennifer S, Carle, Georges F, Carleton, Gillian, Carloni, Silvia, CarmonaGutierrez, Didac, Carneiro, Leticia A, Carnevali, Oliana, Carosi, Julian M, Carra, Serena, Carrier, Alice, Carrier, Lucie, Carroll, Bernadette, Carter, A Brent, Carvalho, Andreia Neves, Casanova, Magali, Casas, Caty, Casas, Josefina, Cassioli, Chiara, Castillo, Eliseo F, Castillo, Karen, CastilloLluva, Sonia, Castoldi, Francesca, Castori, Marco, Castro, Ariel F, CastroCaldas, Margarida, CastroHernandez, Javier, CastroObregon, Susana, Catz, Sergio D, Cavadas, Claudia, Cavaliere, Federica, Cavallini, Gabriella, Cavinato, Maria, Cayuela, Maria L, Rica, Paula Cebollada, Cecarini, Valentina, Cecconi, Francesco, CechowskaPasko, Marzanna, Cenci, Simone, CeperueloMallafre, Victoria, Cerqueira, Joao J, Cerutti, Janete M, Cervia, Davide, Cetintas, Vildan Bozok, Cetrullo, Silvia, Chae, HanJung, Chagin, Andrei S, Chai, CheeYin, Chakrabarti, Gopal, Chakrabarti, Oishee, Chakraborty, Tapas, Chakraborty, Trinad, Chami, Mounia, Chamilos, Georgios, Chan, David W, Chan, Edmond Y W, Chan, Edward D, Chan, H Y Edwin, Chan, Helen H, Chan, Hung, Chan, Matthew T, V, Chan, Yau Sang, Chandra, Partha K, Chang, ChihPeng, Chang, Chunmei, Chang, HaoChun, Chang, Kai, Chao, Jie, Chapman, Tracey, CharletBerguerand, Nicolas, Chatterjee, Samrat, Chaube, Shail K, Chaudhary, Anu, Chauhan, Santosh, Chaum, Edward, Checler, Frederic, Cheetham, Michael E, Chen, ChangShi, Chen, GuangChao, Chen, JianFu, Chen, Liam L, Chen, Leilei, Chen, Lin, Chen, Mingliang, Chen, MuKuan, Chen, Ning, Chen, Quan, Chen, RueyHwa, Chen, Shi, Chen, Wei, Chen, Weiqiang, Chen, XinMing, Chen, XiongWen, Chen, Xu, Chen, Yan, Chen, YeGuang, Chen, Yingyu, Chen, Yongqiang, Chen, YuJen, Chen, YueQin, Chen, Zhefan Stephen, Chen, Zhi, Chen, ZhiHua, Chen, Zhijian J, Chen, Zhixiang, Cheng, Hanhua, Cheng, Jun, Cheng, ShiYuan, Cheng, Wei, Cheng, Xiaodong, Cheng, XiuTang, Cheng, Yiyun, Cheng, Zhiyong, Chen, Zhong, Cheong, Heesun, Cheong, Jit Kong, Chernyak, Boris, V, Cherry, Sara, Cheung, Chi Fai Randy, Cheung, Chun Hei Antonio, Cheung, KingHo, Chevet, Eric, Chi, Richard J, Chiang, Alan Kwok Shing, Chiaradonna, Ferdinando, Chiarelli, Roberto, Chiariello, Mario, Chica, Nathalia, Chiocca, Susanna, Chiong, Mario, Chiou, ShihHwa, Chiramel, Abhilash, I, Chiurchiu, Valerio, Cho, DongHyung, Choe, SeongKyu, Choi, Augustine M K, Choi, Mary E, Choudhury, Kamalika Roy, Chow, Norman S, Chu, Charleen T, Chua, Jason P, Chua, John Jia En, Chung, Hyewon, Chung, Kin Pan, Chung, Seockhoon, Chung, SoHyang, Chung, YuenLi, Cianfanelli, Valentina, Ciechomska, Iwona A, Cifuentes, Mariana, Cinque, Laura, Cirak, Sebahattin, Cirone, Mara, Clague, Michael J, Clarke, Robert, Clementi, Emilio, Coccia, Eliana M, Codogno, Patrice, Cohen, Ehud, Cohen, Mickael M, Colasanti, Tania, Colasuonno, Fiorella, Colbert, Robert A, Colell, Anna, Coll, Nuria S, Collins, Mark O, Colombo, Maria, I, ColonRamos, Daniel A, Combaret, Lydie, Comincini, Sergio, Cominetti, Marcia R, Consiglio, Antonella, Conte, Andrea, Conti, Fabrizio, Contu, Viorica Raluca, Cookson, Mark R, Coombs, Kevin M, Coppens, Isabelle, Corasaniti, Maria Tiziana, Corkery, Dale P, Cordes, Nils, Cortese, Katia, Costa, Maria do Carmo, Costantino, Sarah, Costelli, Paola, CotoMontes, Ana, Crack, Peter J, Crespo, Jose L, Criollo, Alfredo, Crippa, Valeria, Cristofani, Riccardo, Csizmadia, Tamas, Cuadrado, Antonio, Cui, Bing, Cui, Jun, Cui, Yixian, Cui, Yong, Culetto, Emmanuel, Cumino, Andrea C, Cybulsky, Andrey, V, Czaja, Mark J, Czuczwar, Stanislaw J, DAdamo, Stefania, DAmelio, Marcello, DArcangelo, Daniela, DLugos, Andrew C, DOrazi, Gabriella, da Silva, James A, Dafsari, Hormos Salimi, Dagda, Ruben K, Dagdas, Yasin, Daglia, Maria, Dai, Xiaoxia, Dai, Yun, Dai, Yuyuan, Dal Col, Jessica, Dalhaimer, Paul, Dalla Valle, Luisa, Dallenga, Tobias, Dalmasso, Guillaume, Damme, Markus, Dando, Ilaria, Dantuma, Nico P, Darling, April L, Das, Hiranmoy, Dasarathy, Srinivasan, Dasari, Santosh K, Dash, Srikanta, Daumke, Oliver, Dauphinee, Adrian N, Davies, Jeffrey S, Davila, Valeria A, Davis, Roger J, Davis, Tanja, Naidu, Sharadha Dayalan, De Amicis, Francesca, De Bosscher, Karolien, De Felice, Francesca, De Franceschi, Lucia, De Leonibus, Chiara, de Mattos Barbosa, Mayara G, De Meyer, Guido R Y, De Milito, Angelo, De Nunzio, Cosimo, De Palma, Clara, De Santi, Mauro, De Virgilio, Claudio, De Zio, Daniela, Debnath, Jayanta, DeBosch, Brian J, Decuypere, JeanPaul, Deehan, Mark A, Deflorian, Gianluca, DeGregori, James, Dehay, Benjamin, Del Rio, Gabriel, Delaney, Joe R, Delbridge, Lea M D, DelormeAxford, Elizabeth, Delpino, M Victoria, Demarchi, Francesca, Dembitz, Vilma, Demers, Nicholas D, Deng, Hongbin, Deng, Zhiqiang, Dengjel, Joern, Dent, Paul, Denton, Donna, DePamphilis, Melvin L, Der, Channing J, Deretic, Vojo, Descoteaux, Albert, Devis, Laura, Devkota, Sushil, Devuyst, Olivier, Dewson, Grant, Dharmasivam, Mahendiran, Dhiman, Rohan, di Bernardo, Diego, Di Cristina, Manlio, Di Domenico, Fabio, Di Fazio, Pietro, Di Fonzo, Alessio, Di Guardo, Giovanni, Di Guglielmo, Gianni M, Di Leo, Luca, Di Malta, Chiara, Di Nardo, Alessia, Di Rienzo, Martina, Di Sano, Federica, Diallinas, George, Diao, Jiajie, DiazAraya, Guillermo, DiazLaviada, Ines, Dickinson, Jared M, Diederich, Marc, Dieude, Melanie, Dikic, Ivan, Ding, Shiping, Ding, WenXing, Dini, Luciana, Dinic, Miroslav, DinkovaKostova, Albena T, Dionne, Marc S, Distler, Jorg H W, Diwan, Abhinav, Dixon, Ian M C, DjavaheriMergny, Mojgan, Dobrinski, Ina, Dobrovinskaya, Oxana, Dobrowolski, Radek, Dobson, Renwick C J, Emre, Serap Dokmeci, Donadelli, Massimo, Dong, Bo, Dong, Xiaonan, Dong, Zhiwu, Ii, Gerald W Dorn, Dotsch, Volker, Dou, Huan, Dou, Juan, Dowaidar, Moataz, Dridi, Sami, Drucker, Liat, Du, Ailian, Du, Caigan, Du, Guangwei, Du, HaiNing, Du, LiLin, du Toit, Andre, Duan, ShaoBin, Duan, Xiaoqiong, Duarte, Sonia P, Dubrovska, Anna, Dunlop, Elaine A, Dupont, Nicolas, Duran, Raul, V, Dwarakanath, Bilikere S, Dyshlovoy, Sergey A, EbrahimiFakhari, Darius, Eckhart, Leopold, Edelstein, Charles L, Efferth, Thomas, Eftekharpour, Eftekhar, Eichinger, Ludwig, Eid, Nabil, Eisenberg, Tobias, Eissa, N Tony, Eissa, Sanaa, Ejarque, Miriam, El Andaloussi, Abdeljabar, ElHage, Nazira, ElNaggar, Shahenda, Eleuteri, Anna Maria, ElShafey, Eman S, Elgendy, Mohamed, Eliopoulos, Aristides G, Elizalde, Maria M, Elks, Philip M, Elsasser, HansPeter, Elsherbiny, Eslam S, Emerling, Brooke M, Emre, N C Tolga, Eng, Christina H, Engedal, Nikolai, Engelbrecht, AnnaMart, Engelsen, Agnete S T, Enserink, Jorrit M, Escalante, Ricardo, Esclatine, Audrey, EscobarHenriques, Mafalda, Eskelinen, EevaLiisa, Espert, Lucile, Eusebio, MakandjouOla, Fabrias, Gemma, Fabrizi, Cinzia, Facchiano, Antonio, Facchiano, Francesco, Fadeel, Bengt, Fader, Claudio, Faesen, Alex C, Fairlie, W Douglas, Falco, Alberto, Falkenburger, Bjorn H, Fan, Daping, Fan, Jie, Fan, Yanbo, Fang, Evandro F, Fang, Yanshan, Fang, Yognqi, Fanto, Manolis, FarfelBecker, Tamar, Faure, Mathias, Fazeli, Gholamreza, Fedele, Anthony O, Feldman, Arthur M, Feng, Du, Feng, Jiachun, Feng, Lifeng, Feng, Yibin, Feng, Yuchen, Feng, Wei, Araujo, Thais Fenz, Ferguson, Thomas A, FernandezCheca, Jose C, FernandezVeledo, Sonia, Fernie, Alisdair R, Ferrante, Anthony W, Jr, Ferraresi, Alessandra, Ferrari, Merari F, Ferreira, Julio C B, FerroNovick, Susan, Figueras, Antonio, Filadi, Riccardo, Filigheddu, Nicoletta, FilippiChiela, Eduardo, Filomeni, Giuseppe, Fimia, Gian Maria, Fineschi, Vittorio, Finetti, Francesca, Finkbeiner, Steven, Fisher, Edward A, Fisher, Paul B, Flamigni, Flavio, Fliesler, Steven J, Flo, Trude H, Florance, Ida, Florey, Oliver, Florio, Tullio, Fodor, Erika, Follo, Carlo, Fon, Edward A, Forlino, Antonella, Fornai, Francesco, Fortini, Paola, Fracassi, Anna, Fraldi, Alessandro, Franco, Brunella, Franco, Rodrigo, Franconi, Flavia, Frankel, Lisa B, Friedman, Scott L, Frohlich, Leopold F, Fruhbeck, Gema, Fuentes, Jose M, Fujiki, Yukio, Fujita, Naonobu, Fujiwara, Yuuki, Fukuda, Mitsunori, Fulda, Simone, Furic, Luc, Furuya, Norihiko, Fusco, Carmela, Gack, Michaela U, Gaffke, Lidia, Galadari, Sehamuddin, Galasso, Alessia, Galindo, Maria F, Kankanamalage, Sachith Gallolu, Galluzzi, Lorenzo, Galy, Vincent, Gammoh, Noor, Gan, Boyi, Ganley, Ian G, Gao, Feng, Gao, Hui, Gao, Minghui, Gao, Ping, Gao, ShouJiang, Gao, Wentao, Gao, Xiaobo, Garcera, Ana, Garcia, Maria Noe, Garcia, Veronica E, GarciaDel Portillo, Francisco, GarciaEscudero, Vega, GarciaGarcia, Aracely, GarciaMacia, Marina, GarciaMoreno, Diana, GarciaRuiz, Carmen, GarciaSanz, Patricia, Garg, Abhishek D, Gargini, Ricardo, Garofalo, Tina, Garry, Robert F, Gassen, Nils C, Gatica, Damian, Ge, Liang, Ge, Wanzhong, GeissFriedlander, Ruth, Gelfi, Cecilia, Genschik, Pascal, Gentle, Ian E, Gerbino, Valeria, Gerhardt, Christoph, Germain, Kyla, Germain, Marc, Gewirtz, David A, Afshar, Elham Ghasemipour, Ghavami, Saeid, Ghigo, Alessandra, Ghosh, Manosij, Giamas, Georgios, Giampietri, Claudia, Giatromanolaki, Alexandra, Gibson, Gary E, Gibson, Spencer B, Ginet, Vanessa, Giniger, Edward, Giorgi, Carlotta, Girao, Henrique, Girardin, Stephen E, Giridharan, Mridhula, Giuliano, Sandy, Giulivi, Cecilia, Giuriato, Sylvie, Giustiniani, Julien, Gluschko, Alexander, Goder, Veit, Goginashvili, Alexander, Golab, Jakub, Goldstone, David C, Golebiewska, Anna, Gomes, Luciana R, Gomez, Rodrigo, GomezSanchez, Ruben, GomezPuerto, Maria Catalina, GomezSintes, Raquel, Gong, Qingqiu, Goni, Felix M, GonzalezGallego, Javier, GonzalezHernandez, Tomas, GonzalezPolo, Rosa A, GonzalezReyes, Jose A, GonzalezRodriguez, Patricia, Goping, Ing Swie, Gorbatyuk, Marina S, Gorbunov, Nikolai, V, Gorojod, Roxana M, Gorski, Sharon M, Goruppi, Sandro, Gotor, Cecilia, Gottlieb, Roberta A, Gozes, Illana, Gozuacik, Devrim, 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HarhajiTrajkovic, Ljubica, Hariharan, Nirmala, Haroon, Nigil, Harris, James, Hasegawa, Takafumi, Nagoor, Noor Hasima, Haspel, Jeffrey A, Haucke, Volker, Hawkins, Wayne D, Hay, Bruce A, Haynes, Cole M, Hayrabedyan, Soren B, Hays, Thomas S, He, Congcong, He, Qin, He, RongRong, He, YouWen, He, YuYing, Heakal, Yasser, Heberle, Alexander M, Hejtmancik, J Fielding, Helgason, Gudmundur Vignir, Henkel, Vanessa, Herb, Marc, Hergovich, Alexander, HermanAntosiewicz, Anna, Hernandez, Agustin, Hernandez, Carlos, HernandezDiaz, Sergio, HernandezGea, Virginia, Herpin, Amaury, Herreros, Judit, Hervas, Javier H, Hesselson, Daniel, Hetz, Claudio, Heussler, Volker T, Higuchi, Yujiro, Hilfiker, Sabine, Hill, Joseph A, Hlavacek, William S, Ho, Emmanuel A, Ho, Idy H T, Ho, Philip WingLok, Ho, ShuLeong, Ho, Wan Yun, Hobbs, G Aaron, Hochstrasser, Mark, Hoet, Peter H M, Hofius, Daniel, Hofman, Paul, Hohn, Annika, Holmberg, Carina, I, Hombrebueno, Jose R, Hong, ChangWon, Hong, YiRen, Hooper, Lora, V, Hoppe, 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CELL CHEMICAL BIOLOGY[J]. 2021, 28(6):&nbsp855-+, http://dx.doi.org/10.1016/j.chembiol.2021.04.020.[7] Zhang, Haijiao, Lin, Lin, Liu, Jianping, Pan, Lifeng, Lin, Zhijie, Zhang, Mingjie, Zhang, Jiong, Cao, Ying, Zhu, Jinwei, Zhang, Rongguang. Phase Separation of MAGI2-Mediated Complex Underlies Formation of Slit Diaphragm Complex in Glomerular Filtration Barrier. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY[J]. 2021, 32(8):&nbsp1946-1960, [8] Fu, Tao, Zhang, Mingfang, Zhou, Zixuan, Wu, Ping, Peng, Chao, Wang, Yingli, Gong, Xinyu, Li, Ying, Wang, Yaru, Xu, Xiaolong, Li, Miao, Shen, Liqiang, Pan, Lifeng. Structural and biochemical advances on the recruitment of the autophagy-initiating ULK and TBK1 complexes by autophagy receptor NDP52. SCIENCE ADVANCES[J]. 2021, 7(33):&nbsp[9] Liu, Guizhen, Fu, Tao, Han, Ying, Hu, Shichen, Zhang, Xuepei, Zheng, Mengmeng, Hao, Piliang, Pan, Lifeng, Kang, Jingwu. Probing Protein-Protein Interactions with Label-Free Mass Spectrometry Quantification in Combination with Affinity Purification by Spin-Tip Affinity Columns. ANALYTICAL CHEMISTRY[J]. 2020, 92(5):&nbsp3913-3922, https://www.webofscience.com/wos/woscc/full-record/WOS:000518234700057.[10] Li, Ying, Cheng, Xiaofang, Li, Miao, Wang, Yingli, Fu, Tao, Zhou, Zixuan, Wang, Yaru, Gong, Xinyu, Xu, Xiaolong, Liu, Jianping, Pan, Lifeng. Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(35):&nbsp21391-21402, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474698/.[11] Kangmin Hua, Xiangyang Liu, Yuchun Zhao, Yaojie Gao, Lifeng Pan, Haoran Zhang, Zixin Deng, Ming Jiang. Offloading Role of a Discrete Thioesterase in Type II Polyketide Biosynthesis. MBIO[J]. 2020, 11(5):&nbsphttp://dx.doi.org/10.1128/mBio.01334-20.[12] Qingfei, Zheng, Yukang, Gong, Yujiao, Guo, Zhixiong, Zhao, Zhuhua, Wu, Zixuan, Zhou, Dandan, Chen, 潘李锋, 刘文. 吡咯吲哚霉素生源合成过程中催化反式十氢萘生成的黄素腺嘌呤二核苷酸依赖的4+2环化酶的结构透视. 科学新闻. 2019, 134-134, http://lib.cqvip.com/Qikan/Article/Detail?id=75888869504849574850494951.[13] Shichen Hu, Yujiao Guo, Yingli Wang, Ying Li, Tao Fu, Zixuan Zhou, Yaru Wang, Jianping Liu, Lifeng Pan. Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering. Nature Communications[J]. 2019, 10(1):&nbsp1-12, https://doaj.org/article/945bfe09b3fb4db79823e2b763ce2484.[14] Pan, Lifeng, Liu, Jianping, Li, Ying, Qin, ZH. Structural Basis of Autophagy Regulatory Proteins. AUTOPHAGY: BIOLOGY AND DISEASES: BASIC SCIENCE[J]. 2019, 1206: 285-324, [15] Carrion, Maria Perez, Pischedda, Francesca, Biosa, Alice, Russo, Isabella, Straniero, Letizia, Civiero, Laura, Guida, Marianna, Gloeckner, Christian J, Ticozzi, Nicola, Tiloca, Cinzia, Mariani, Claudio, Pezzoli, Gianni, Duga, Stefano, Pichler, Irene, Pan, Lifeng, Landers, John E, Greggio, Elisa, Hess, Michael W, Goldwurm, Stefano, Piccoli, Giovanni. The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP plus Treatment by Altering LRRK2 Binding to DRP1. FRONTIERS IN MOLECULAR NEUROSCIENCE[J]. 2018, 11: https://www.webofscience.com/wos/woscc/full-record/WOS:000426267500001.[16] Zheng, Qingfei, Gong, Yukang, Guo, Yujiao, Zhao, Zhixiong, Wu, Zhuhua, Zhou, Zixuan, Chen, Dandan, Pan, Lifeng, Liu, Wen. Structural Insights into a Flavin-Dependent 4+2 Cyclase that Catalyzes trans-Decalin Formation in Pyrroindomycin Biosynthesis. CELL CHEMICAL BIOLOGY[J]. 2018, 25(6):&nbsp718-+, http://dx.doi.org/10.1016/j.chembiol.2018.03.007.[17] Fu, Tao, Liu, Jianping, Wang, Yingli, Xie, Xingqiao, Hu, Shichen, Pan, Lifeng. Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(50):&nbspE11651-E11660, https://www.webofscience.com/wos/woscc/full-record/WOS:000452866000012.[18] Xu, Daichao, Jin, Taijie, Zhu, Hong, Chen, Hongbo, Ofengeim, Dimitry, Zou, Chengyu, Mifflin, Lauren, Pan, Lifeng, Amin, Palak, Li, Wanjin, Shan, Bing, Naito, Masanori Gomi, Meng, Huyan, Li, Ying, Pan, Heling, Aron, Liviu, Adiconis, Xian, Levin, Joshua Z, Yankner, Bruce A, Yuan, Junying. TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. CELL[J]. 2018, 174(6):&nbsp1477-+, http://dx.doi.org/10.1016/j.cell.2018.07.041.[19] Li, Faxiang, Xu, Daichao, Wang, Yingli, Zhou, Zixuan, Liu, Jianping, Hu, Shichen, Gong, Yukang, Yuan, Junying, Pan, Lifeng. Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation. AUTOPHAGY[J]. 2018, 14(1):&nbsp66-79, https://www.webofscience.com/wos/woscc/full-record/WOS:000427049900006.[20] Maria Perez Carrion, Francesca Pischedda, Alice Biosa, Isabella Russo, Letizia Straniero, Laura Civiero, Marianna Guida, Christian J Gloeckner, Nicola Ticozzi, Cinzia Tiloca, Claudio Mariani, Gianni Pezzoli, Stefano Duga, Irene Pichler, Lifeng Pan, John E Landers, Elisa Greggio, Michael W Hess, Stefano Goldwurm, Giovanni Piccoli. The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1. Frontiers in Molecular Neuroscience[J]. 2018, 11: https://doaj.org/article/966cd6a9f2404d1fad07e6bf77e844ea.[21] Hu, Shichen, Wang, Yingli, Gong, Yukang, Liu, Jianping, Li, Ying, Pan, Lifeng. Mechanistic Insights into Recognitions of Ubiquitin and Myosin VI by Autophagy Receptor TAX1BP1. JOURNAL OF MOLECULAR BIOLOGY[J]. 2018, 430(18):&nbsp3283-3296, http://dx.doi.org/10.1016/j.jmb.2018.06.030.[22] Liu, Jianping, Pan, Lifeng. Structural bases of the assembly, recognition and disassembly of linear ubiquitin chain. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCHnull. 2018, 1865(10):&nbsp1410-1422, http://dx.doi.org/10.1016/j.bbamcr.2018.07.003.[23] Wei, Ran, Xu, Lily Wen, Liu, Jianping, Li, Yanxia, Zhang, Pei, Shan, Bing, Lu, Xiaojuan, Qian, Lihui, Wu, Zheming, Dong, Kangyun, Zhu, Hong, Pan, Lifeng, Yuan, Junying, Pan, Heling. SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination. GENES & DEVELOPMENT[J]. 2017, 31(11):&nbsp1162-1176, https://www.webofscience.com/wos/woscc/full-record/WOS:000405578600010.[24] Liu, Jianping, Wang, Yingli, Gong, Yukang, Fu, Tao, Hu, Shichen, Zhou, Zixuan, Pan, Lifeng. Structural Insights into SHARPIN-Mediated Activation of HOIP for the Linear Ubiquitin Chain Assembly. CELL REPORTS[J]. 2017, 21(1):&nbsp27-36, http://dx.doi.org/10.1016/j.celrep.2017.09.031.[25] Zhang, Zhuan, Gong, YuKang, Zhou, Qiang, Hu, Yu, Ma, HongMin, Chen, YongSheng, Igarashi, Yasuhiro, Pan, Lifeng, Tang, GongLi. Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 114(7):&nbsp1554-1559, https://www.webofscience.com/wos/woscc/full-record/WOS:000393989300056.[26] Xu, Daichao, Liu, Jianping, Fu, Tao, Shan, Bing, Qian, Lihui, Pan, Lifeng, Yuan, Junying. USP25 regulates Wnt signaling by controlling the stability of tankyrases. GENES & DEVELOPMENT[J]. 2017, 31(10):&nbsp1024-1035, https://www.webofscience.com/wos/woscc/full-record/WOS:000403831200007.[27] Zheng, Qingfei, Guo, Yujiao, Yang, Linlin, Zhao, Zhixiong, Wu, Zhuhua, Zhang, Hua, Liu, Jianping, Cheng, Xiaofang, Wu, Jiequn, Yang, Huaiyu, Jiang, Hualiang, Pan, Lifeng, Liu, Wen. Enzyme-Dependent 4+2 Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4. CELL CHEMICAL BIOLOGY[J]. 2016, 23(3):&nbsp352-360, http://dx.doi.org/10.1016/j.chembiol.2016.01.005.[28] Faxiang Li, Xingqiao Xie, Yingli Wang, Jianping Liu, Xiaofang Cheng, Yujiao Guo, Yukang Gong, Shichen Hu, Lifeng Pan. Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins. NATURE COMMUNICATIONS[J]. 2016, 7(1):&nbsphttps://doaj.org/article/6f149eadfad341e89e90455b3ba5ac86.[29] Cheng, Xiaofang, Wang, Yingli, Gong, Yukang, Li, Faxiang, Guo, Yujiao, Hu, Shichen, Liu, Jianping, Pan, Lifeng. Structural basis of FYCO1 and MAP1LC3A interaction reveals a novel binding mode for Atg8-family proteins. AUTOPHAGY[J]. 2016, 12(8):&nbsp1330-1339, https://www.webofscience.com/wos/woscc/full-record/WOS:000382309200008.[30] Gong, Yukang, Pan, Lifeng. Recent advances in bioorthogonal reactions for site-specific protein labeling and engineering. TETRAHEDRON LETTERS[J]. 2015, 56(17):&nbsp2123-2132, http://dx.doi.org/10.1016/j.tetlet.2015.03.065.[31] Xie, Xingqiao, Li, Faxiang, Wang, Yuanyuan, Wang, Yingli, Lin, Zhijie, Cheng, Xiaofang, Liu, Jianping, Chen, Changbin, Pan, Lifeng. Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2. AUTOPHAGY[J]. 2015, 11(10):&nbsp1775-1789, https://www.webofscience.com/wos/woscc/full-record/WOS:000363867800006.[32] Xu, Daichao, Shan, Bing, Lee, ByungHoon, Zhu, Kezhou, Zhang, Tao, Sun, Huawang, Liu, Min, Shi, Linyu, Liang, Wei, Qian, Lihui, Xiao, Juan, Wang, Lili, Pan, Lifeng, Finley, Daniel, Yuan, Junying. Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system. ELIFE[J]. 2015, 4: https://doaj.org/article/9d282bdce61146f5b224b2708265e62a.[33] Xia, Hongguang, Najafov, Ayaz, Geng, Jiefei, GalanAcosta, Lorena, Han, Xuemei, Guo, Yuan, Shan, Bing, Zhang, Yaoyang, Norberg, Erik, Zhang, Tao, Pan, Lifeng, Liu, Junli, Coloff, Jonathan L, Ofengeim, Dimitry, Zhu, Hong, Wu, Kejia, Cai, Yu, Yates, John R, Zhu, Zhengjiang, Yuan, Junying, VakifahmetogluNorberg, Helin. Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. JOURNAL OF CELL BIOLOGY[J]. 2015, 210(5):&nbsp705-716, https://www.webofscience.com/wos/woscc/full-record/WOS:000360685600006.[34] Piccoli, Giovanni, Onofri, Franco, Cirnaru, Maria Daniela, Kaiser, Christoph J O, Jagtap, Pravinkumar, Kastenmueller, Andreas, Pischedda, Francesca, Marte, Antonella, von Zweydorf, Felix, Vogt, Andreas, Giesert, Florian, Pan, Lifeng, Antonucci, Flavia, Kiel, Christina, Zhang, Mingjie, Weinkauf, Sevil, Sattler, Michael, Sala, Carlo, Matteoli, Michela, Ueffing, Marius, Gloeckner, Christian Johannes. Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain. MOLECULAR AND CELLULAR BIOLOGY[J]. 2014, 34(12):&nbsp2147-2161, https://www.webofscience.com/wos/woscc/full-record/WOS:000336743200004.[35] 张明杰. IL-1β and reactive oxygen species differentially regulate neutrophil directional migration and Basal random motility in a zebrafish injury-induced inflammation model. J Immunol. 2014, [36] VAKIFAHMETOGLUNORBERG HELIN, KIM MINSU, XIA HONGGUANG, IWANICKI MARCIN P, OFENGEIM DIMITRY, COLOFF JONATHAN L, Pan Lifeng, INCE TAN A, KROEMER GUIDO, BRUGGE JOAN S, Yuan Junying. Chaperone-mediated autophagy degrades mutant p53. Genes Dev.[J]. 2013, 27(15):&nbsp1718-1730, http://www.irgrid.ac.cn/handle/1471x/870641.[37] VakifahmetogluNorberg, Helin, Kim, Minsu, Xia, Hongguang, Iwanicki, Marcin P, Ofengeim, Dimitry, Coloff, Jonathan L, Pan, Lifeng, Ince, Tan A, Kroemer, Guido, Brugge, Joan S, Yuan, Junying. Chaperone-mediated autophagy degrades mutant p53. GENES & DEVELOPMENT[J]. 2013, 27(15):&nbsp1718-1730, http://www.irgrid.ac.cn/handle/1471x/870641.[38] 张明杰. Membrane-induced lever arm expansion allows myosin VI to walk with large and variable step sizes. J Biol ChemAugust30. 2012, [39] Pan, Lifeng, Zhang, Mingjie. Structures of Usher Syndrome 1 Proteins and Their Complexes. PHYSIOLOGYnull. 2012, 27(1):&nbsp25-42, https://www.webofscience.com/wos/woscc/full-record/WOS:000300408000004.[40] Li, Xiaohua, He, Liqiang, Che, Ka Hing, Funderburk, Sarah F, Pan, Lifeng, Pan, Nina, Zhang, Mingjie, Yue, Zhenyu, Zhao, Yanxiang. Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG. NATURE COMMUNICATIONS[J]. 2012, 3: 662-, https://www.webofscience.com/wos/woscc/full-record/WOS:000302060100003.[41] 张明杰. Cargo Recognition Mechanism of Myosin X Revealed by the Structure of its Tail MyTH4-FERM Tandem in Complex with the DCC P3 Domain. PNAS. 2011, [42] 张明杰. The Structure of the PDZ3-SH3-GuK Tandem of ZO-1 Suggests a Supramodular Organization of the MAGUK Family Scaffold Protein Core. J Biol Chem. 2011, [43] FENG Wei, PAN LiFeng, ZHANG MingJie. Combination of NMR spectroscopy and X-ray crystallography offers unique advantages for elucidation of the structural basis of protein complex assembly. 中国科学：生命科学英文版. 2011, 54(2):&nbsp101-111, http://lib.cqvip.com/Qikan/Article/Detail?id=36779055.[44] 张明杰. Structure of MyTH4-FERM Domains in Myosin VIIa Tail Bound to Cargo. Science[J]. 2011, 331(6018):&nbsp757-760, https://www.webofscience.com/wos/woscc/full-record/WOS:000287205700067.[45] Feng Wei, Pan LiFeng, Zhang MingJie. Combination of NMR spectroscopy and X-ray crystallography offers unique advantages for elucidation of the structural basis of protein complex assembly. SCIENCE CHINA-LIFE SCIENCES[J]. 2011, 54(2):&nbsp101-111, http://www.irgrid.ac.cn/handle/1471x/757425.[46] 张明杰. quot Redox-regulated lipid membrane binding of the PICK1 PDZ domain of the two Usher syndrome proteins. Biochemistry. 2010, [47] 张明杰. The Structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteins. PNAS. 2010, [48] 张明杰. Extensions of PDZ domains as important structural and functional elements. Protein & Cellnull. 2010, 1(8):&nbsp737-751, https://www.webofscience.com/wos/woscc/full-record/WOS:000208511300008.[49] Wen, Wenyu, Yu, Jiang, Pan, Lifeng, Wei, Zhiyi, Weng, Jingwei, Wang, Wenning, Ong, Yan Shan, Tran, Ton Hoai Thi, Hong, Wanjin, Zhang, Mingjie. Lipid-Induced Conformational Switch Controls Fusion Activity of Longin Domain SNARE Ykt6. MOLECULAR CELL[J]. 2010, 37(3):&nbsp383-395, http://dx.doi.org/10.1016/j.molcel.2010.01.024.[50] 韩家淮. Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding. Proceedings of the National Academy of Sciences of the United States of America[J]. 2010, 107(49):&nbsp20974-20979, https://www.webofscience.com/wos/woscc/full-record/WOS:000285050800026.[51] 张明杰. Assembling Stable Hair-Cell Tip Link Complex via Multi-dentate Interactions between Harmonin and Cadherin23. PNAS. 2009, [52] 张明杰. Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites. EMBO J. 2008, [53] 张明杰. Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes. EMBO J. 2007, [54] Wu Lin, Pan Lifeng, Zhang Chuchu, Zhang Mingjie. Large Protein Assemblies Formed by Multivalent Interactions between Cadherin23 and Harmonin Suggest a Stable Anchorage Structure at the Tip Link of Stereocilia *. The Journal of Biological Chemistry. 287(40):&nbsp33460-33471, http://dx.doi.org/10.1074/jbc.M112.378505.[55] Xia Hong-guang, Najafov Ayaz, Geng Jiefei, Galan-Acosta Lorena, Han Xuemei, Guo Yuan, Shan Bing, Zhang Yaoyang, Norberg Erik, Zhang Tao, Pan Lifeng, Liu Junli, Coloff Jonathan L., Ofengeim Dimitry, Zhu Hong, Wu Kejia, Cai Yu, Yates John R., Zhu Zhengjiang, Yuan Junying, Vakifahmetoglu-Norberg Helin. Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. The Journal of Cell Biology. 210(5):&nbsp705-716, https://www.webofscience.com/wos/woscc/full-record/WOS:000360685600006.
科研活动
科研项目
（ 1 ）&nbsp调控生命过程的若干天然产物的合成、靶点和机制研究, 参与, 国家级, 2013-01--2017-12（ 2 ）&nbsp中组部国家****项目, 主持, 国家级, 2013-01--2015-12（ 3 ）&nbsp细胞坏死小分子抑制剂Nec29的作用机制及相关的化学生物学研究, 主持, 省级, 2013-07--2015-06（ 4 ）&nbsp国家自然科学基金面上项目, 主持, 国家级, 2015-01--2018-12（ 5 ）&nbsp合成科学与生物创制专题, 参与, 省级, 2015-07--2018-06（ 6 ）&nbsp天然产物的化学生物学, 参与, 国家级, 2017-01--2022-12（ 7 ）&nbsp神经退行性疾病中细胞死亡机理和干预的研究, 参与, 国家级, 2016-06--2021-05（ 8 ）&nbsp几个新颖[4+2]环加成酶的结构及其催化机制研究, 主持, 国家级, 2017-01--2020-12（ 9 ）&nbsp天然产物生源合成过程中催化环化反应的几个新颖蛋白酶的结构、催化机制和改良应用研究, 主持, 省级, 2017-09--2020-08（ 10 ）&nbsp蛋白质线性泛素化修饰的分子机制和小分子调控研究, 主持, 国家级, 2018-01--2020-12（ 11 ）&nbsp蛋白-蛋白相互作用和蛋白-小分子相互作用的机制研究, 主持, 国家级, 2019-01--2021-12
指导学生
已指导学生张帅琰 硕士研究生 070303-有机化学 李发祥 博士研究生 071009-细胞生物学 程小芳 博士研究生 071009-细胞生物学 郭玉娇 硕士研究生 085238-生物工程 龚余康 博士研究生 0703Z1-化学生物学 现指导学生胡世尘 博士研究生 0703Z1-化学生物学 龚新宇 硕士研究生 070303-有机化学 李淼 硕士研究生 070303-有机化学 付涛 博士研究生 0703Z1-化学生物学 周子璇 博士研究生 0703Z1-化学生物学 许晓龙 博士研究生 070303-有机化学 王亚茹 博士研究生 0703Z1-化学生物学 李颖 博士研究生 0703Z1-化学生物学 张明芳 硕士研究生 070303-有机化学
2013 中国科学院大学，网络信息中心.